serine hydroxymethyltransferase (SHMT), serine methylase or glycine hydroxymethyltransferase

Function

• catalyzes formation of 5,10-methylenetetrahydrofolate & glycine from serine & tetrahydrofolate
• the methylenetetrahydrofolate is, in turn, used by thymidylate synthase in the biosynthesis of dTMP from dUMP

More general terms

• transferase

More specific terms

• serine hydroxymethyltransferase, cytosolic; SHMT; glycine hydroxymethyltransferase; serine methylase (SHMT1)
• serine hydroxymethyltransferase, mitochondrial; SHMT; glycine hydroxymethyltransferase; serine methylase (SHMT2)

Additional terms

• thymidylate synthase; TS; TSase (TYMS, TS, OK/SW-cl29)