serine hydroxymethyltransferase, mitochondrial; SHMT; glycine hydroxymethyltransferase; serine methylase (SHMT2)
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Function
- interconversion of serine & glycine
- one-carbon metabolism; tetrahydrofolate interconversion
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
- pyridoxal phosphate
- homotetramer
Structure
belongs to the SHMT family
Compartment
Notes
- in eukaryotes there are two forms of the enzymes: acytosolic one & a mitochondrial one