serine hydroxymethyltransferase, cytosolic; SHMT; glycine hydroxymethyltransferase; serine methylase (SHMT1)

Function

• interconversion of serine & glycine
• one-carbon metabolism; tetrahydrofolate interconversion

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

Cofactor: pyridoxal phosphate

Structure

• homotetramer
• belongs to the SHMT family

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Notes

• in eukaryotes there are two forms of the enzymes: a cytosolic one & a mitochondrial one

More general terms

• serine hydroxymethyl transferase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6470
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6470
• OMIM: https://mirror.omim.org/entry/182144
• UniProt: http://www.uniprot.org/uniprot/P34896.html