follicle center lymphoma, grade III (follicular large cell lymphoma)
Jump to navigation
Jump to search
Introduction
Intermediate-grade lymphoma.
Classification
- working formulation
- follicular, predominantly large cell
- Rappaport
- nodular, histiocytic
- Lukes-Collins
- FCC*, large cleaved &/or non-cleaved
- Kiel
* FCC: follicular center cells
Epidemiology
- uncommon
- < 15% of follicular lymphomas
Pathology
- neoplastic B-cells
- large cells, with cleaved or non-cleaved nuclei
- mitotic figures common
- prone to develop into diffuse lymphoma early in their course
Management
- R-CHOP (rituximab, cyclophosphamaide, doxorubicin, vincristine & prednisone) induction[3]
- maintenance for 2 years with rituximab[3]
- hematopoietic stem cell transplantation may be appropriate for relapse[3]
- prognosis poorer than with other follicular lymphomas
More general terms
Additional terms
References
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 712-713
- ↑ Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994 Sep 1;84(5):1361-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8068936
- ↑ 3.0 3.1 3.2 3.3 Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012