lymphomatous meningitis

Introduction

Metastatic non Hodgkin's lymphoma to the CNS typically involves leptomeninges, rarely the brain & usually in the setting of advanced disseminated disease.

Primary leptomeningeal lymphoma in the absence of brain involvement is rare, ~7%.

Clinical manifestations

• progressive leg weakness
• urinary incontinence
• cranial neuropathies
• increased intracranial pressure
• confusion

Laboratory

• CSF:
• lymphocytic pleocytosis/malignant lymphocytes
• low glucose, ~1/3
• elevated protein

Radiology

• gadolinium MRI:
• meningeal enhancement
• hydrocephalus
• intradural nodules

More general terms

• meningitis
• non-Hodgkin's lymphoma
• meningeal neoplasm

Patient information

lymphomatous meningitis patient information