classification of non-Hodgkin's lymphoma

Introduction

Based on Working Formulation.

Classification

• Low-Grade
• small lymphocytic
  • Rappaport
    • lymphocytic, well differentiated
  • Lukes-Collins
    • small lymphocyte & plasmacytoid lymphocytic
• follicular, predominantly small cleaved cell*
  • Rappaport
    • nodular, poorly differentiated lymphocytic
  • Lukes-Collins
    • FCC#, small, cleaved
  • Kiel
    • centroblastic-centrocytic lymphoma, follicular
• follicular, mixed small cleaved & large cell
  • Rappaport
    • nodular, mixed lymphocytic histiocytic
  • Lukes-Collins
    • FCC#, small cleaved & large cleaved
  • Kiel
    • centroblastic-centrocytic lymphoma, follicular
• Intermediate-Grade
  • follicular, predominantly large cell
  • Rappaport
    • nodular, histiocytic
  • Lukes-Collins
    • FCC#, large cleaved &/or noncleaved
  • Kiel
    • centroblastic lymphoma, follicular
  • diffuse, small cleaved cell
  • Rappaport
    • diffuse, poorly differentiated lymphocytic
  • Lukes-Collins
    • FCC#, small cleaved diffuse
  • diffuse, mixed small & large cell
  • Rappaport
    • diffuse, mixed lymphocytic & histiocytic
  • Lukes-Collins
    • FCC#, small cleaved, large cleaved, or large noncleaved
  • diffuse, large cell
  • Rappaport
    • diffuse histiocytic
  • Lukes-Collins
    • FCC#, large cleaved or noncleaved
• High-Grade
  • large cell, immunoblastic
  • Rappaport
    • diffuse histiocytic
  • Lukes-Collins
    • immunoblastic B-cell or T-cell type
  • lymphoblastic
  • Rappaport
    • lymphoblastic lymphoma
  • Lukes-Collins
    • convoluted T-cell lymphoma
  • small non cleaved cell
  • Rappaport
    • undifferentiated, Burkitt's & non Burkitt's
  • Lukes-Collins
    • FCC#, small noncleaved

* most common form

# follicle center cells

More general terms

• classification