LETM1 domain-containing protein 1 (cervical cancer 1 proto-oncogene protein p40, cervical cancer proto-oncogene 2 protein, HCRR-2, LETMD1)

Function

• role in tumorigenesis & may function as a negative regulator of the TP53/p53

Structure

contains 1 LETM1 domain

Compartment

membrane (putative)

Alternative splicing

named isoforms=6

Expression

• kidney, liver, skeletal muscle, heart & brain

Pathology

• overexpressed in various tumors including leukemia, lymphoma, & carcinomas of the breast, kidney, ovary, stomach, colon & uterine cervix

More general terms

• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6P1Q0.html