developmentally-regulated GTP-binding protein 1; DRG-1; neural cell expressed developmentally down-regulated protein 3; NEDD-3 (DRG1, NEDD3)

Function

• may play a role in cell proliferation, differentiation & cell death
• polyubiquitinated
  • induces proteolytic degradation
  • impaired by interaction with ZC3H15 (putative)
• sumoylated by UBE2I in response to MEKK1-mediated stimuli
• binds to SCL/TAL1, TAL2 & LYL1 (putative)
• interacts with ZC3H15

Structure

• C-terminal domain interacts with TAL1 (putative)
• belongs to the GTP1/OBG family

Compartment

cytoplasm

Expression

• expressed at high levels in skeletal muscle, heart, & kidney
• expressed at intermediate levels in liver, placenta & brain
• expressed at low levels in colon, thymus, spleen, small intestine, lung & leukocytes
• expression induced by androgens

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4733
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4733
• OMIM: https://mirror.omim.org/entry/603952
• UniProt: http://www.uniprot.org/uniprot/Q9Y295.html