lyl-1 proto-oncogene protein; lymphoblastic leukemia-derived sequence 1 (LYL1)
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Function
- efficient DNA binding requires dimerization with another bHLH protein
Structure
contains 1 basic helix-loop-helix (bHLH) domain
Compartment
Pathology
- chromosomal translocation t(7;19)(q35;p13) involving LYL1 with TCRB is associated with T-cell acute lymphoblastic leukemia (T-ALL)
More general terms
- basic helix loop helix (bHLH) family transcription factor
- transcription factor (TF)
- proto oncogene protein
References
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/LYL1ID51ch19p13.html
- ↑ UniProt http://www.uniprot.org/uniprot/P12980.html