T-cell acute lymphocytic leukemia-2 protein (TAL2)

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Pathology

• chromosomal translocation t(7;9)(q34;q32) involving TAL2 with TCRB is associated with T-cell acute lymphoblastic leukemia (T-ALL)

More general terms

• basic helix loop helix (bHLH) family transcription factor
• transcription factor (TF)
• proto oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6887
• OMIM: https://mirror.omim.org/entry/186855
• UniProt: http://www.uniprot.org/uniprot/Q16559.html