ETS-related transcription factor Elf-2; E74-like factor 2; new ETS-related factor (ELF2, NERF)

Function

• isoform 1 transcriptionally activates LYN & BLK promoters
  • acts synergistically with RUNX1 to transactivate BLK promoter
• isoform 2 transcriptional repression of RUNX1 (putative)
• interacts with LIM domains of LMO2
• interacts with RUNX1

Compartment

• nucleus

Alternative splicing

• named isoforms=5

Expression

• expressed ubiquitously in fetal & adult tissues
• in fetal tissues, expression in heart, lung, liver, kidney > brain
• in adult tissues, expression in heart, placenta, lung, skeletal muscle, spleen, thymus, testis, ovary > prostate, small intestine, kidney, liver, pancreas > colon, brain, peripheral blood lymphocytes

More general terms

• ETS-related transcription factor Elf
• DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q15723.html