mesoderm induction early response protein 1 (Mi-er1, hmi-er1, early response 1, Er1, MIER1, KIAA1610)

Function

• transcriptional repressor of a number of genes including Sp1 target genes
• interacts with HDAC1

Structure

• contains 1 ELM2 domain
• contains 1 SANT domain

Compartment

• isoforms 1,2,3: nucleus
• isoforms 4,5,6: cytoplasm

Expression

• ubiquitously expressed, but at very low levels
• consistent level of expression are observed in heart, testis, thyroid, ovary & adrenal gland

Pathology

• transcripts are up-regulated in breast carcinoma cell lines breast cancer

More general terms

• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N108.html