protein BANP (Btg3-associated nuclear protein, scaffold/matrix-associated region-1-binding protein, BANP, SMAR1)

Function

• controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function
• binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer
• represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thus diminishing H3K9ac, H3S10ph & H4K8ac levels
• promotes TP53 Ser-15 phosphorylation & nuclear accumulation, which causes cell cycle arrest (putative)
• interacts with TP53 & CUTL1/CDP (putative)
• interacts with HDAC1
• part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 & RBL2

Structure

belongs to the BANP/SMAR1 family

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

down-regulated in breast cancer cell lines

More general terms

• nuclear protein

Component of

• corepressor complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N9N5.html