homeobox protein TGIF2; 5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2 (TGIF2)

Function

• transcriptional repressor
• probably represses transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins
• probably represses transcription via the recruitment of histone deacetylase proteins
• the C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway
• interacts with the transcriptional modulator SMAD3 & the histone deacetylase HDAC1

Structure

• belongs to the TALE/TGIF homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

• nucleus
• excluded from nucleoli

Expression

• widely expressed
• highly expressed in heart, kidney & testis
• weakly expressed in brain & prostate Pahtology:
• TGIF2 is amplified & overexpressed in several ovarian cancer cell lines

More general terms

• homeobox protein
• phosphoprotein
• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=60436
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:60436
• OMIM: https://mirror.omim.org/entry/607294
• UniProt: http://www.uniprot.org/uniprot/Q9GZN2.html