homeobox protein TGIF1; 5'-TG-3'-interacting factor 1; TGFB-induced factor (TGIF1 TGIF)

Function

• binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE)
• inhibits 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element
• active transcriptional corepressor of SMAD2
• links the nodal signaling pathway to the bifurcation of the forebrain & establishment of ventral midline structures
• may participate in transmission of nuclear signals during development & in the adult, as suggested by the down-modulation of RXR alpha activities
• interacts with CTBP, SMAD2, SMAD3 & HDAC1

Structure

• belongs to the TALE/TGIF homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Pathology

• mutations associated with holoprosencephaly type 4

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7050
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7050
• OMIM: https://mirror.omim.org/entry/142946
• OMIM: https://mirror.omim.org/entry/602630
• UniProt: http://www.uniprot.org/uniprot/Q15583.html