BHC histone deacetylase complex

Function

• corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells
• recruited at NRSE sites by REST
• deacetylates & demethylates specific sites on histones
• may recruit chromatin-remodeling SWI-SNF complex
• within the complex:
  • RCOR1 enhances demethylase activity of AOF2 & protects it from the proteasome
  • PHF21A inhibits demethylase activity of AOF2

Structure

• consists of:
  • HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST, RCOR2, PHF21A/BHC80, ZNF198, ZNF217, ZMYM3, KIAA0182, GTF2I, PHF21A GSE1

More general terms

• molecular complex