SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; SMARCE1-related protein; HMG box-containing protein 20B; HMG domain-containing protein HMGX2; HMG domain-containing protein 2; structural DNA-binding protein BRAF35; BRCA2-associated factor 35; Sox-like transcriptional factor (HMG20B, BRAF35, HMGX2, HMGXB2, SMARCE1R)

Function

• required for correct progression through G2 phase of the cell cycle & entry into mitosis
• required for RCOR1/CoREST mediated repression of neuronal specific gene promoters
• component of a BHC histone deacetylase complex

interacts with the BRCA2 tumor suppressor protein

Structure

• contains 1 HMG box DNA-binding domain

Compartment

• nucleus
• localized to condensed chromosomes in mitosis in conjunction with BRCA2

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed in adult tissues

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily E
• nuclear protein

Component of

• BHC histone deacetylase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10362
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10362
• OMIM: https://mirror.omim.org/entry/605535
• UniProt: http://www.uniprot.org/uniprot/Q9P0W2.html