REST corepressor 1 (protein CoREST, RCOR1, KIAA0071, RCOR)

Function

• component of the BHC complex
• in the BHC complex, RCOR1 recruits MeCP2 & SUV39H1
• role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of AOF2/LSD1 on core histones & nucleosomal substrates
• protects AOF2/LSD1 from the proteasome
• SANT domains may bridge the nucleosomal substrates & the demethylase AOF2/LSD1

Structure

• belongs to the CoREST family
• contains 1 ELM2 domain
• contains 2 SANT domains

Compartment

nucleus

Expression

ubiquitously expressed

Pathology

• interacts directly with herpes virus HSV-1 ICP0 protein, leading to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes
• upon infection by HSV-1, partially translocated into cytoplasm
• phosphorylated by HSV-1 protein kinases

More general terms

• protein subunit

Component of

• BHC histone deacetylase complex

Database

• OMIM: https://mirror.omim.org/entry/607675
• UniProt: http://www.uniprot.org/uniprot/Q9UKL0.html