histone acetyltransferase PCAF; histone acetylase PCAF; P300/CBP-associated factor; P/CAF (PCAF, KAT2B)

Function

• histone acetyltransferase
• promotes transcriptional activation
• as significant histone acetyltransferase activity with core histones (H3 & H4), & also with nucleosome core particles
• inhibits cell-cycle progression & counteracts the mitogenic activity of the adenoviral oncoprotein E1A
• interacts with SIRT1 (putative)
• interacts with EP300 & CREBBP
• interacts with NCOA1 & NCOA3. component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 & KIF11/TRIP5
• binds to HTLV-1 Tax
• interacts with & acetylates HIV-1 Tat
• interacts with KLF1; the interaction does not acetylate KLF1 & there is no enhancement of its transactivational activity
• interacts with NFE4

Structure

• the bromodomain mediates binding to HIV-1 Tat
• belongs to the GCN5 family
• contains 1 bromo domain
• contains 1 N-acetyltransferase domain

Compartment

nucleus (putative)

Expression

• ubiquitously expressed
• most abundant in heart & skeletal muscle

Pathology

• in case of HIV-1 infection, PCAF is recruited by the viral protein Tat; PCAF regulates Tat's transactivating activity & may help inducing chromatin remodeling of proviral genes

More general terms

• nuclear protein
• histone acetyltransferase
• phosphoprotein

Component of

• PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8850
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8850
• OMIM: https://mirror.omim.org/entry/602303
• UniProt: http://www.uniprot.org/uniprot/Q92831.html