transcription factor NF-E4 (NFE4)

Function

• part of the SSP complex (stage selector protein complex)
• interacts with HDAC1 & PCAF
• acetylation at Lys-43 prolongs the protein half-life by preventing ubiquitin-mediated degradation & diminishes interaction between NF-E4 & HDAC1, potentially maximizing activating ability of the factor
• ubiquitination leads to its degradation by the proteasome
• acetylation at Lys-43 prevents ubiquitination
• isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 & RNA polymerase 2 recruitment to the gamma-globin gene promoter . isoform 2 interacts with TFCP2

Compartment

nucleus (probable)

Alternative initiation

named isoforms=2

Expression

• specifically expressed in fetal liver, cord blood & bone marrow
• also expressed in the K562 & HEL cell lines, which constitutively express the fetal globin genes

More general terms

• transcription factor (TF)

Component of

• stage selector protein complex (SSP complex)

Database

• OMIM: https://mirror.omim.org/entry/612133
• UniProt: http://www.uniprot.org/uniprot/Q86UQ8.html