kinesin-like 1 protein; kinesin-like protein KIF11; kinesin family member 11; kinesin-related motor protein Eg5; kinesin-like spindle protein HKSP; thyroid receptor-interacting protein 5 (KNSL1, KIF11, TRIP5, EG5)

Function

• motor protein required for establishing a bipolar spindle
• blocking of KIF11 prevents centrosome migration & arrests cells in mitosis with monoastral microtubule arrays
• interacts with the thyroid hormone receptor in the presence of thyroid hormone
• phosphorylated exclusively on Ser during S phase, but on both Ser & Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the kinesin-like protein family, BimC subfamily
• contains 1 kinesin-motor domain

More general terms

• kinesin family protein
• thyroid hormone receptor interacting protein (TRIP)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/148760
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3832
• UniProt: http://www.uniprot.org/uniprot/P52732.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3832