RNA-binding protein 10; RNA-binding motif protein 10; G patch domain-containing protein 9; RNA-binding protein S1-1; S1-1 (RBM10, DXS8237E, GPATC9, GPATCH9, KIAA0122)

Function

• may be involved in post-transcriptional processing, most probably in mRNA splicing
• binds to RNA homopolymers, with a preference for poly(G) & poly(U) & little for poly(A)
• phosphorylated upon DNA damage, probably by ATM or ATR
• associates with the spliceosome
• component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 & KIF11/TRIP5

Structure

• contains 1 C2H2-type Zn+2 finger
• contains 1 G-patch domain
• contains 1 RanBP2-type Zn+2 finger
• contains 2 RRM domain (RNA recognition motif)s

Compartment

• nucleus
• in the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner
• upon globally reducing RNA polymerase 2 transcription, the nuclear bodies enlarge & decrease in number
• they occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains)

Alternative splicing

named isoforms=4

More general terms

• RNA-binding motif protein
• nuclear protein
• C2H2 type zinc finger protein
• phosphoprotein

More specific terms

• ribosome biogenesis inhibitor MINAS-60 (MINAS-60)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8241
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8241
• OMIM: https://mirror.omim.org/entry/300080
• UniProt: http://www.uniprot.org/uniprot/P98175.html