ribosome biogenesis inhibitor MINAS-60 (MINAS-60)

Function

• acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus
• interacts with 60S ribosome assembly factors GTPBP4 & MRTO4

Compartment

• nucleus, nucleolus

Alternative splicing

alternative initiation; named isoforms=6

Expression

• increases at early S phase & peaks during S phase
• decreases by late S phase & is very low during G2/M
• at G1, it again increases

Notes

• MINAS-60 is the product of an alternative open reading frame (alt-ORF) of transcripts coding for the RBM10 (AC P98175) protein
• MINAS-60 & RBM10 ORFs are overlapping & are formed by shifting the reading frame

More general terms

• RNA-binding protein 10

Database

• UniProt: http://www.uniprot.org/uniprot/P0DW28.html