MYC-induced nuclear antigen (Mineral dust-induced gene protein, nucleolar protein 52, MINA, MDIG, MINA53, NO52)

Function

• role in cellular proliferation
• role in cell growth & survival
• may be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles

Structure

contains 1 JmjC domain

Compartment

nucleus, nucleus, nucleolus

Alternative splicing

named isoforms=3

Expression

• expressed in liver, skeletal muscle, heart, pancreas, & placenta
• t detected in brain, lung or kidney

Pathology

• expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues
• highly expressed in several esophageal squamous cell carcinoma & colon cancer tissues, & in various cancer cell lines
• up-regulated in response to MYC, in alveolar macrophages from coal miners & in silica particle-treated A549 lung cancer cells

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IUF8.html