CCAAT/enhancer-binding protein-delta; C/EBP delta; nuclear factor NF-IL6-beta; NF-IL6-beta (CEBPD)

Function

• C/EBP is a DNA-binding protein that recognizes two different motifs:
  • CCAAT homology common to many promoters
  • enhanced core homology common to many enhancers
• transcriptional activator in the regulation of genes involved in immune & inflammatory responses
• role in regulation of activation &/or differentiation of macrophages
• binds DNA as a dimer & can form stable heterodimers with C/EBP alpha
• interacts with SPI1/PU.1 (putative)

Structure

• belongs to the bZIP family, C/EBP subfamily
• contains 1 bZIP domain

Compartment

nucleus

More general terms

• CCAAT/enhancer binding protein (C/EBP, CBF, NF-Y protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1052
• OMIM: https://mirror.omim.org/entry/116898
• UniProt: http://www.uniprot.org/uniprot/P49716.html