CCAAT/enhancer-binding protein-beta; C/EBP beta; nuclear factor NF-IL6; transcription factor 5 (CEBPB, TCF5, PP9092)

Function

• transcriptional activator
• role in regulation of immune & inflammatory responses
• specifically binds to an IL-1 response element in the IL-6 gene
• role in hippocampal memory consolidation via upregulatation of IGF2
• NF-IL6 also binds to regulatory regions of several acute-phase & cytokines genes
• role in regulation of acute-phase reaction, inflammation & hemopoiesis
• consensus recognition site is 5'-T[TG]NNGNAA[TG]-3' binds DNA as a dimer & can form stable heterodimers with C/EBP alpha, C/EBP delta & C/EBP gamma
• interacts with TRIM28 & PTGES2 (putative)
• sumoylated by polymeric chains of SUMO2 or SUMO3

Structure

• belongs to the bZIP family, C/EBP subfamily
• contains 1 bZIP domain

Compartment

nucleus

Expression

expressed at low levels in the lung, kidney & spleen

More general terms

• CCAAT/enhancer binding protein (C/EBP, CBF, NF-Y protein)

Additional terms

• interleukin-6 dependent DNA binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P17676.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1051
• OMIM: https://mirror.omim.org/entry/189965