prostaglandin E synthase 2 (microsomal prostaglandin E synthase 2, mPGES-2, PTGES2, PGES2)

Function

• isomerase intermediate of prostaglandin E2 H2 (PGH2) into more stable prostaglandin E2 (PGE2) form
• transactivation activity toward IFN-gamma via interaction with CEBPB (putative, relevance uncertain)
• cofactor: dihydro lipoic acid
• prostaglandin biosynthesis 5)interact with CEBPB (putative), EXOSC1

Structure

homodimer

Compartment

• Golgi membrane
• processed form: cytoplasm, perinuclear region

Expression

• widely expressed in adult & heart but not aorta
• expressed in brain: cerebellum; occipital lobe, frontal lobe & parietal lobes
• expressed in the lymph nodes, skeletal muscle, kidney, trachea
• not expressed in thymus, lung

Pathology

• overexpressed in colorectal cancer

More general terms

• isomerase
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/608152
• UniProt: http://www.uniprot.org/uniprot/Q9H7Z7.html