phosphatidate phosphatase LPIN1; lipin-1 (LPIN1, KIAA0188)
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Function
- roles in controlling metabolism of fatty acids at differents levels
- Mg+2-dependent phosphatidate phosphatase
- catalyzes conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine & phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane
- also a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (putative)
- role in adipocyte differentiation (putative)
- inhibited by N-ethylmaleimide (putative)
- phosphorylated at multiple sites in response to insulin
- phosphorylation is controlled by the mTOR signaling pathway
- dephosphorylated in response to epinephrine & oleic acid (putative)
- sumoylated (putative)
- interacts (via LXXIL motif) with PPARA (putative)
- interacts with PPARGC1A (putative)
- interaction with PPARA & PPARGC1A leads to the formation of a complex that modulates gene transcription (putative)
- interacts with MEF2C
Structure
- contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA (putative)
- contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity
- belongs to the lipin family
Compartment
Expression
- abundant in adipose tissue & skeletal muscle
- lower levels in some portions of the digestive tract
Pathology
- defects in LPIN1 are a cause of acute recurrent rhabdomyolysis
Notes
- candidate gene for human lipodysytropy syndromes