AH receptor-interacting protein; AIP; aryl-hydrocarbon receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2; XAP-2 (AIP, XAP2)

Function

• positive role in AHR (aromatic hydrocarbon receptor) signaling (putative), possibly by influencing its receptivity for ligand &/or its nuclear targeting
• negative regulator of the hepatitis B virus (HBV) X protein

Structure

• contains 1 PPIase FKBP-type domain
• contains 2 TPR repeats

Compartment

cytoplasm

Expression

• widely expressed
• higher levels seen in the heart, placenta & skeletal muscle
• not expressed in the liver

Pathology

• defects in AIP are a cause of
  • pituitary adenoma predisposition
  • familial isolated pituitary adenoma
  • growth hormone-secreting pituitary adenoma
  • ACTH-secreting pituitary adenoma
  • prolactin-secreting pituitary adenoma

More general terms

• carrier protein (transporter)
• isomerase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9049
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9049
• OMIM: https://mirror.omim.org/entry/102200
• OMIM: https://mirror.omim.org/entry/219090
• OMIM: https://mirror.omim.org/entry/600634
• OMIM: https://mirror.omim.org/entry/605555
• UniProt: http://www.uniprot.org/uniprot/O00170.html