cullin-associated NEDD8-dissociated protein 1; cullin-associated & neddylation-dissociated protein 1; TBP-interacting protein of 120 kD A; TBP-interacting protein 120A; p120 CAND1 (CAND1, KIAA0829, TIP120, TIP120A)

Function

• enhances transcription from various types of promoters
• regulatory protein that interferes with the assembly of SCF ubiquitin ligase complex (SKP1-CUL1-F-box protein complex)
  • down-regulates ubiquitination of target proteins
• prevents neddylation of CUL1 by physically blocking access to neddylation site
• disrupts interactions between CUL1 & SKP1A & between CUL1 & F-box proteins
• binds TBP
• bomponent of complex that contains CUL1 & RBX1
• binds unneddylated CUL1, but cannot bind CUL1 once neddylated
• binds CUL2, CUL3, CUL4A, CUL4B, CUL5

Structure

• belongs to the CAND family
• contains 27 HEAT repeats

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein
• nuclear protein
• HEAT repeat-containing protein (HEATR)

Additional terms

• cullin
• NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55832
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55832
• OMIM: https://mirror.omim.org/entry/607727
• UniProt: http://www.uniprot.org/uniprot/Q86VP6.html