protein fem-1 homolog B (FEM1-beta, FEM1b, Fem-1-like death receptor-binding protein alpha, F1A-alpha, FEM1B, F1AA, KIAA0396)

Function

• component of an ECS E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit
• involved in apoptosis by acting as a death receptor- associated protein that mediates apoptosis
• also involved in glucose homeostasis in pancreatic islet
• protein degradation; protein ubiquitination
• interacts with PPM1F & PHTF1
• interacts with the death domain of FAS/TNFRSF6 & TNFRSF1A

Structure

• homooligomer
• belongs to the fem-1 family
• contains 8 ANK repeats
• contains 1 TPR repeat

Compartment

cytoplasm (putative)

Expression

• widely expressed
• expressed in testis > other tissues

More general terms

• receptor
• ankyrin repeat domain protein (ANKRD)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1011
• UniProt: http://www.uniprot.org/uniprot/Q9UK73.html