protein phosphatase 1F; Ca+2/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; partner of PIX 2; protein fem-2 homolog; hFem-2 (PPM1F, KIAA0015, POPX2)

Function

• dephosphorylates & concomitantly deactivates
  • CaM-kinase 2 activated upon autophosphorylation
  • CaM-kinase 1 & CaM-kinase 4 activated upon phosphorylation by CaM-kinase kinase
• promotes apoptosis
• associates with FEM1B

Cofactor:

• binds 2 Mg+2 or Mn+2 per subunit

Structure

belongs to the PP2C family

More general terms

• phosphoprotein phosphatase
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9647
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9647
• UniProt: http://www.uniprot.org/uniprot/P49593.html