amyloid beta precursor protein binding protein 1; NEDD8-activating enzyme E1 regulatory subunit; amyloid protein-binding protein 1; amyloid beta precursor protein-binding protein 1 59 kD; APP-binding protein 1; APP-BP1; protooncogene protein 1 (NAE1, HPP1, APPBP1)

Function

• protein neddylation
• regulatory subunit of the dimeric UBE1C-APPBP1 E1 enzyme
  • NEDD8 conjugation, 1st step
  • transfers NEDD8 to the catalytic Cys of UBE2M
• cell cycle progression through the S-M checkpoint.
• overexpression of APPBP1 causes apoptosis via deregulation of NEDD8 conjugation.
• binding of TP53BP2 to the regulatory subunit APPBP1 decreases neddylation activity
• heterodimer of UBE1C & APPBP1, binds NEDD8 & UBE2M
• binds APP & TP53BP2

Structure

• belongs to the ubiquitin-activating E1 family, ULA1 subfamily

Compartment

• cell membrane
• colocalizes with APP in lipid rafts

Expression

• ubiquitous in fetal tissues
• expressed throughout the adult brain

Notes

• NAE1 & UBA3 correspond to the N-terminal & the C-terminal part of yeast UBA3
• in yeast the two subunits form a single polypeptide chain

More general terms

• cell surface receptor

Additional terms

• amyloid precursor protein; A4/beta amyloid precursor protein (APP)
• NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C)
• NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8883
• OMIM: https://mirror.omim.org/entry/603385
• UniProt: http://www.uniprot.org/uniprot/Q13564.html