sentrin-specific protease 8; deneddylase-1; NEDD8-specific protease 1; protease, cysteine 2; sentrin/SUMO-specific protease SENP8 (SENP8, DEN1, NEDP1, PRSC2, FKSG8)

Function

• protease that catalyzes two essential functions in the NEDD8 pathway:
  • processing of full-length NEDD8 to its mature form
  • deconjugation of NEDD8 from targeted proteins such as cullins or p53

Kinetic parameters:

• KM=51 nM for Nedd8-AMC
• KM for Ub-AMC exceeds 5uM

Structure

• belongs to the peptidase C48 family

Expression

• broadly expressed
• highest levels in kidney & pancreas

More general terms

• sentrin-specific protease (SUMO-specific protease)

Additional terms

• SUMO protein (small ubiquitin-related modifier)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=123228
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:123228
• OMIM: https://mirror.omim.org/entry/608659
• UniProt: http://www.uniprot.org/uniprot/Q96LD8.html