high-mobility group [HMG] protein

Introduction

A group of non-histone proteins found in chromatin

Function

• their role has not been definitively established
• they are believed to have a role in nuclear matrix stabilization, protection of single-stranded DNA, & are required for transcription

More general terms

• nuclear protein

More specific terms

• high mobility group nucleosome-binding domain-containing protein 4; non-histone chromosomal protein HMG-17-like 3 (HMGN4, HMG17L3, NHC)
• high mobility group protein 20A (HMG box-containing protein 20A, HMG domain-containing protein HMGX, HMG20A, HMGX1)
• high mobility group protein B1; high mobility group protein 1; HMG-1; amphoterin (HMGB1, HMG1)
• high mobility group protein B2; high mobility group protein 2; HMG-2 (HMGB2, HMG2)
• high mobility group protein B3; high mobility group protein 4; HMG-4; high mobility group protein 2a; HMG-2a (HMGB3, HMG2A, HMG4)
• high mobility group protein B4 (HMGB4)
• high mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group AT-hook protein 1; high mobility group protein A1; high mobility group protein R (HMGA1 HMGIY)
• high mobility group protein HMGI-C; high mobility group AT-hook protein 2 (HMGA2 HMGIC)
• high-mobility group protein 1-like 2; hepatoma-derived growth factor; HDGF; HMG-1L2 (HDGF, HMG1L2)
• HMG domain-containing protein 4; HMG box-containing protein 4; high mobility group protein 2-like 1; protein HMGBCG (HMGXB4, HMG2L1, HMGBCG)
• interferon-induced 17 kD protein; contains: ubiquitin cross-reactive protein; hUCRP; interferon-induced 15 kD protein (IFP17, ISG15, G1P2, UCRP)
• NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)
• non-histone chromosomal protein HMG-14; high-mobility group nucleosome-binding domain-containing protein 1 (HMGN1 HMG14)
• non-histone chromosomal protein HMG-17; high-mobility group nucleosome-binding domain-containing protein 2 (HMGN2, HMG17)
• SUMO protein (small ubiquitin-related modifier)
• TOX high mobility group box family
• ubiquitin (UBCEP2, UBB, UBC)
• ubiquitin-like protein FUBI (FAU)