high-mobility group protein 1-like 2; hepatoma-derived growth factor; HDGF; HMG-1L2 (HDGF, HMG1L2)

Function

• heparin-binding protein, with mitogenic activity for fibroblasts
• acts as a transcriptional repressor
• sumoylated by SUMO1
• sumoylation prevents binding to chromatin

Structure

• monomer, & domain-swapped homodimer
• the PWWP domain harbors the heparin-binding sites & is responsible for DNA-binding
• C-terminal region is essentially unstructured
• belongs to the HDGF family
• contains 1 PWWP domain

Compartment

cytoplasm, nucleus

Expression

ubiquitous

More general terms

• high-mobility group [HMG] protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3068
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3068
• OMIM: https://mirror.omim.org/entry/600339
• UniProt: http://www.uniprot.org/uniprot/P51858.html