high mobility group protein B1; high mobility group protein 1; HMG-1; amphoterin (HMGB1, HMG1)
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Function
- mediates neurite outgrowth when present extracellularly
- ligand for RAGE
- binding to RAGE effects immune function of dendritic cells[3][4]
- may function as proinflammatory cytokine[9][10][11][12]
- as nuclear protein, binds preferentially single-stranded DNA & unwinds double stranded DNA
Structure
- belongs to the HMGB family
- contains 2 HMG box DNA-binding domains
Compartment
Expression
- strongly expressed in developing neurons
Pathology
More general terms
References
- ↑ Bergeron S, Madathiparambil T, Swanson PC. Both HMG-boxes and the acidic tail of HMGB1 regulate RAG- mediated recombination signal synapsis and cleavage in vitro. J Biol Chem. 2005 Jul 1; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/15994314
- ↑ Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P. HMGB1: guiding immunity from within. Trends Immunol. 2005 Jul;26(7):381-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15978523
- ↑ 3.0 3.1 Dumitriu IE, Baruah P, Valentinis B, Voll RE, Herrmann M, Nawroth PP, Arnold B, Bianchi ME, Manfredi AA, Rovere-Querini P. Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J Immunol. 2005 Jun 15;174(12):7506-15. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15944249
- ↑ 4.0 4.1 Dumitriu IE, Baruah P, Bianchi ME, Manfredi AA, Rovere-Querini P. Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells. Eur J Immunol. 2005 Jul;35(7):2184-90. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15915542
- ↑ Najima Y, Yahagi N, Takeuchi Y, Matsuzaka T, Sekiya M, Nakagawa Y, Amemiya-Kudo M, Okazaki H, Okazaki S, Tamura Y, Iizuka Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Yamada N, Osuga JI, Shimano H. High mobility group protein-B1 (HMGB1) interacts with sterol regulatory element-binding proteins (SREBPs) to enhance their DNA binding. J Biol Chem. 2005 May 12; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/15894544
- ↑ Najima Y, Yahagi N, Takeuchi Y, Matsuzaka T, Sekiya M, Nakagawa Y, Amemiya-Kudo M, Okazaki H, Okazaki S, Tamura Y, Iizuka Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Yamada N, Osuga JI, Shimano H. High mobility group protein-B1 (HMGB1) interacts with sterol regulatory element-binding proteins (SREBPs) to enhance their DNA binding. J Biol Chem. 2005 May 12; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/15894544
- ↑ 7.0 7.1 Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. J Neurosci Res. 2004 Dec 15;78(6):880-91. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15499593
- ↑ Palumbo R, Bianchi ME. High mobility group box 1 protein, a cue for stem cell recruitment. Biochem Pharmacol. 2004 Sep 15;68(6):1165-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15313414
- ↑ 9.0 9.1 Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Muller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep. 2004 Aug;5(8):825-30. Epub 2004 Jul 23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15272298
- ↑ 10.0 10.1 Andersson U, Tracey KJ. HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis. Rheum Dis Clin North Am. 2004 Aug;30(3):627-37, xi. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15261345
- ↑ 11.0 11.1 Chen G, Ward MF, Sama AE, Wang H. Extracellular HMGB1 as a proinflammatory cytokine. J Interferon Cytokine Res. 2004 Jun;24(6):329-33. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15212706
- ↑ 12.0 12.1 Erlandsson Harris H, Andersson U. Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator. Eur J Immunol. 2004 Jun;34(6):1503-12. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15162419
- ↑ UniProt http://www.uniprot.org/uniprot/P09429.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/hmgb1/