non-histone chromosomal protein HMG-14; high-mobility group nucleosome-binding domain-containing protein 1 (HMGN1 HMG14)

Function

• binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA & the histone octamer
• may be involved in the process which maintains transcribable genes in an unique chromatin conformation
• inhibits phosphorylation of nucleosomal histones H3 & H2A by RPS6KA5/MSK1 & RPS6KA3/RSK2 (putative)
• phosphorylation on Ser-21 & Ser-25 weakens binding to nucleosomes & increases the rate of H3 phosphorylation
• phosphorylation favors cytoplasmic localization

Structure

belongs to the HMGN family

Compartment

• nucleus, cytoplasm
• cytoplasmic enrichment upon phosphorylation.
• the RNA edited version localizes to the nucleus

RNA editing

• partially edited
• a new initiator Met may be created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids
• the RNA edited version is called ET-HMGN1

More general terms

• high-mobility group [HMG] protein
• DNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3150
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3150
• OMIM: https://mirror.omim.org/entry/163920
• UniProt: http://www.uniprot.org/uniprot/P05114.html