ribosomal S6 kinase-3 (ribosomal protein S6 kinase alpha 2, S6K-alpha 2, 90 kD ribosomal protein S6 kinase 2, p90-RSK 3, RSK-3, pp90RSK3, RPS6KA2)

Function

• serine/threonine kinase
• may play a role in mediating the growth-factor & stress induced activation of the transcription factor CREB
• forms a complex with either ERK1 or ERK2 in quiescent cells
• transiently dissociates following mitogenic stimulation
• activated by multiple phosphorylations on Thr & Ser (putative)
• autophosphorylated on Ser-377, as part of the activation process (putative)

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 2 protein kinase domains

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in many tissues
• highest expression in lung & skeletal muscle

More general terms

• ribosomal protein S6 kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6196
• OMIM: https://mirror.omim.org/entry/601685
• UniProt: http://www.uniprot.org/uniprot/Q15349.html