non-histone chromosomal protein HMG-17; high-mobility group nucleosome-binding domain-containing protein 2 (HMGN2, HMG17)

Function

• binds to the inner side of the nucleosomal DNA thus altering the interaction between DNA & the histone octamer
• may have role in maintenance of transcribable genes in an unique chromatin conformation (putative)
• phosphorylation favors cytoplasmic localization

Structure

belongs to the HMGN family

Compartment

• nucleus, cytoplasm
• cytoplasmic enrichment upon phosphorylation

More general terms

• high-mobility group [HMG] protein
• DNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3151
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3151
• OMIM: https://mirror.omim.org/entry/163910
• UniProt: http://www.uniprot.org/uniprot/P05204.html