high mobility group protein B2; high mobility group protein 2; HMG-2 (HMGB2, HMG2)

Function

• binds preferentially single-stranded DNA
• unwinds double stranded DNA
• component of the SET complex; within the complex, directly interacts with SET

Structure

• belongs to the HMGB family
• contains 2 HMG box DNA-binding domains

Compartment

nucleus

More general terms

• high-mobility group [HMG] protein
• DNA-binding protein
• nonhistone chromosomal protein
• phosphoprotein

Component of

• SET complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3148
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3148
• OMIM: https://mirror.omim.org/entry/163906
• UniProt: http://www.uniprot.org/uniprot/P26583.html