high mobility group protein 20A (HMG box-containing protein 20A, HMG domain-containing protein HMGX, HMG20A, HMGX1)

Function

• role in neuronal differentiation as chromatin-associated protein
• inhibitor of HMG20B
• overcomes repressive effects of the neuronal silencer REST & induces activation of neuronal-specific genes
• role in recruitment of histone methyltransferase MLL & resultant increased methylation of histone H3 lysine 4

Structure

• contains 1 HMG box DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• high-mobility group [HMG] protein

Database

• OMIM: https://mirror.omim.org/entry/605534
• UniProt: http://www.uniprot.org/uniprot/Q9NP66.html