eukaryotic initiation factor 3 subunit 6 (eukaryotic translation initiation factor 3 subunit E, eiF3 p48, mammary tumor-associated protein INT-6, viral integration site protein INT-6, eIF3e, EIF3S6)

Function

• binds to the 40S ribosome & promotes the binding of methionyl-tRNAi & mRNA
• interacts with TRIM27
• interacts with COPS3, COPS6 & COPS7 (COPS7A or COPS7B)
• interacts with EIF3EIP
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the eIF-3 subunit E family
• contains 1 PCI domain

Compartment

cytoplasm

Expression

ubiquitously expressed

More general terms

• eukaryotic initiation factor subunit
• proto oncogene protein
• phosphoprotein

Component of

• eukaryotic initiation factor 3; ribosome dissociation factor (eIF3)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3646
• OMIM: https://mirror.omim.org/entry/602210
• UniProt: http://www.uniprot.org/uniprot/P60228.html