COP9 signalosome complex subunit 3 (signalosome subunit 3, SGN3, JAB1-containing signalosome subunit 3, COPS3, JAB3, CSN3)

Function

• component of the COP9 signalosome complex
• in the complex, interacts directly with COPS1, COPS4 & COPS8
• interacts with CK2, PKD
• interacts with translation initiation factor EIF3S6 & IKBKG
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the CSN3 family
• contains 1 PCI domain

Compartment

cytoplasm, nucleus

Expression

• widely expressed
• expressed at high level in heart, skeletal muscle

Pathology

• amplified & overexpressed in some osteosarcomas

More general terms

• protein subunit
• phosphoprotein

Component of

• COP9 signalosome complex (CSN complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8533
• OMIM: https://mirror.omim.org/entry/604665
• UniProt: http://www.uniprot.org/uniprot/Q9UNS2.html