interferon consensus sequence binding protein 1; interferon response element binding protein (ICSBP, IRF8, ICSBP1)

Function

• specifically binds to the upstream regulatory region of type 1 IFN & IFN-inducible MHC class 1 genes (the interferon consensus sequence (ICS)
• plays a negative regulatory role in cells of the immune system
• interacts with COPS2

Structure

• belongs to the IRF family
• contains 1 tryptophan pentad repeat DNA-binding domain

Compartment

nucleus

Expression

• predominantly in lymphoid tissues
• induced by interferon gamma

More general terms

• interferon regulatory factor family

Database

• UniProt: http://www.uniprot.org/uniprot/Q02556.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3394
• OMIM: https://mirror.omim.org/entry/601565
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3394