nuclear receptor coactivator 7 (140 kD estrogen receptor-associated protein, estrogen nuclear receptor coactivator 1, NCOA7, ERAP140, ESNA1, Nbla00052, Nbla10993)

Function

• enhances transcriptional activities of several nuclear receptors
• role in coactivation of different nuclear receptors, including: ESR1, THRB, PPARG & RARA
• interacts with ESR1, ESR2A, ESR2B, THRB, PPARG & RARA (ligand-inducible)
• interacts with heterodimer AHR-ARNT

Structure

• belongs to the OXR1 family
• contains 1 LysM repeat
• contains 1 TLD domain

Compartment

nucleus

Alternative splicing

named isoforms=6

Expression

• highly expressed in brain
• weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord & pancreas

Pathology

expressed in cancer cell line(s)

More general terms

• nuclear (steroid) receptor coactivator (NRC, SRC, NCoA)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NI08.html