BRCA1-A complex

Function

• specifically recognizes Lys-63-linked ubiquitinated histones H2A & H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs)
• BRCC3 specifically removes Lys-63-linked ubiquitin on histones H2A & H2AX within the complex, antagonizing RNF8-dependent ubiquitination at double-strand breaks

Structure

• subunits:
  • BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 & MERIT40/NBA1

More general terms

• molecular complex

Additional terms

• breast cancer type 1 susceptibility protein (BRCA1)