BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; brain & reproductive organ-expressed protein (BRE, BRCC45)

Function

• component of the BRCA1-A complex
  • in the BRCA1-A complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 & the rest of the complex, thus modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer
  • in the BRCA1-A complex, interacts directly with FAM175A/Abraxas, BRCC3/BRCC36 & BABAM1/NBA1
  • binds polyubiquitin
• role as a component of the BRISC complex (probable)
• component of BRCC complex
• role in homeostasis or cellular differentiation in cells of neural, epithelial & germ line origins
• functions as a death receptor-associated anti-apoptotic protein, which inhibits mitochondrial apoptotic pathway
• may regulate TNF-alpha signaling via interactions with TNFRSF1A

Structure

• contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions
  • these regions lack the critical Cys required for ubiquitination but retain the ability to bind ubiquitin
• belongs to the BRE family

Compartment

• cytoplasm, nucleus
• mainly cytoplasmic, also found in the nucleus
• localizes at sites of DNA damage at double-strand breaks

Alternative splicing

• named isoforms=4
• additional isoforms may exist

Expression

• expressed in all cell lines examined
• highly expressed in placenta
• down-regulated by DNA-damaging agents in fibroblasts, by retinoic acid in brain glioma U-251 & promyelocytic HL-60 cell lines, & by LPS in peripheral blood mononuclear cells

More general terms

• protein subunit
• phosphoprotein
• human longevity protein

Component of

• BRCC holoenzyme complex
• BRISC complex
• BRCA1-A complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9577
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9577
• OMIM: https://mirror.omim.org/entry/610497
• UniProt: http://www.uniprot.org/uniprot/Q9NXR7.html