BRCC holoenzyme complex
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Function
- has Ubc5-dependent ubiquitin E3 ligase activity ubiquitinates C terminus of p53 in vitro
- association with p53 increases after DNA damage
- enhances cellular survival following DNA damage
- truncation of BRCA1 prevented direct association with brcc36
Structure
subunits:
More general terms
References
- ↑ Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003 Nov;12(5):1087-99. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14636569
- ↑ UniProt http://www.uniprot.org/uniprot/Q9NXR7.html
- ↑ UniProt http://www.uniprot.org/uniprot/P46736.html