orphan nuclear receptor NR2E1 (nuclear receptor subfamily 2 group E member 1, nuclear receptor TLX, tailless homolog, Tll, hTll, NR2E1, TLX)

Function

• orphan receptor
• binds DNA as a monomer
  • binds to hormone response elements (HRE) containing extended core motif half-site sequence 5'-AAGGTCA-3'
  • 5' flanking nucleotides participate in determining receptor specificity
• brain development (putative)
• retinal development (putative)

Structure

• monomer
• belongs to the nuclear hormone receptor family, NR2 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus

Expression

• brain specific
• highest levels in the caudate nucleus & hippocampus
• weakest levels in thalamus

More general terms

• orphan receptor
• nuclear hormone receptor family
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7101
• OMIM: https://mirror.omim.org/entry/603849
• UniProt: http://www.uniprot.org/uniprot/Q9Y466.html